![]() ![]() It gives you cool opportunities to do some creative things with colorways that we have.” “We didn’t depart too far from, but the biggest upgrade is the upper,” he explained to Boardroom. “The UA Warp technology still gives you another level of stability, lockdown, and experience. That’s why that’s on my shoes.” Derrick Rose // Adidas DRose Son of ChiĪfter resetting his signature series with Under Armour a year ago with the launch of the Curry 8 Flow and his very own brand, Stephen Curry is back at it this season with his new Splash logo and Flow technology once again powering his latest signature model. “People say, ‘You’re 33, 34, 35, 36 – you can’t do this, you can’t do that,’” he said. Though Chris Paul has continued to switch back and forth between his CP3.12 and CP3.13 models this season, one thing that’s stayed consistent is the motivating phrase he hand-writes along the midsole of each pair in the locker room before every game:Ī lyric from gospel duo Mary Mary, the point guard began writing the phrase during his time in Oklahoma City, before making an immediate impact with the Phoenix Suns and helping lead the franchise to the 2021 NBA Finals. In recent seasons, Paul has utilized the open canvas panels of his CP3 models to highlight dozens of HBCUs, placing collegiate graphics from the likes of FAMU, North Carolina A&T, Hampton, and more onto his player exclusive pairs. The eventual Hall of Famer has since gone on to become one of just eight players in league history to have a signature series extend past 10 models during their career. Bernstein/NBAE via Getty Images)Īfter initially signing with Nike as a rookie, Chris Paul shifted over to Jordan Brand the following season, and became just the second Jumpman athlete after Carmelo Anthony to receive his own signature series during his 3 rd year in the league. I just want to keep providing good moments, keep telling my stories, and make good shoes.” Chris Paul // Jordan CP3.13 (Andrew D. “To be at 14 shoes itself is a great accomplishment to build the brand the way we’ve built it and tell the stories that we’ve told,” he said on Boardroom’s “The Sneaker Game.” “It’s amazing to be a part of a brand like Nike, but to be in that category with MJ and ’Bron, that’s an amazing category. With the release of his newest signature shoe in 2021, Durant became just the third player in league history to see his signature series reach 14 models as an active player. Playing into the ‘Scythe’ weapon of the Grim Reaper, the Slim Reaper’s sneaker incorporates a strap along the upper for the first time since the KD 7, albeit in a uniquely curved design to layer in some added storytelling alongside the launch of KD’s new clothing line of the same name. With his ‘LJ’ crown logo spotted throughout, there is, of course, midsole real estate once again for James to inscribe his series of tributes to family members and friends, or to add his favorite phrases before each game. “There is tremendous growth potential across soft lines, sporting goods and many other fitness areas.At the helm of the league’s longest-ever active signature series for the last five seasons, LeBron is inching closer to a two-decade-long line that will be tough for anyone to top.ĭesigned once again by Jason Petrie, who has penned each ‘Bron silhouette since the 7, the latest edition features more visibly voluminous Air Max and Zoom Air units than ever before, with additional molded Air bladder pockets along the collar and tongue for added padding. “My investment in Pro Player is driven by strong consumer recognition of the brand, combined with the adaptability of the Pro Player trademark to so many product categories,” Ash said. Ash, CEO and president of United Legwear & Apparel, who said he grew up wearing Pro Player, cited the brand’s significant opportunity in today’s fitness-minded market. That philosophy is underscored by Pro Player’s core marketing messaging, “To play like a Pro, you’ve got to train like a Pro.” ![]() The brand’s sales strategy focuses on opening price points, supporting its philosophy that people can achieve aspirational goals while paying an attainable price. Targeted to both team and everyday athletes, as well as fitness enthusiasts, Pro Player’s products are built with performance features such as compression, wicking and ventilation. “The Pro Player brand embodies the active lifestyle that consumers are embracing today. we can combine our footwear design and manufacturing capabilities to help drive more sales.” “Athleisure products - specifically technical and fashion athletics - are driving the footwear business,” said Evan Cagner, Synclaire’s president and CEO. Shoe Executives React to Trump’s Tariff Increase: Proposed Move Would Be ‘Devastating’ Pro Player sneakers. ![]()
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![]() ![]() Hiren’s Boot CD is an incredibly versatile and useful tool for computer repair and maintenance, and the options shown above are just a few tools that you can use to fix or optimize your computer.
![]() ![]() You can’t know the power of iRest unless you practice it. We can’t know what an apple tastes like, unless we taste it. Regular practice - a little and often - enables you to experience the power of iRest and helps you feel connected to yourself, others, and the world around you. ![]() ![]() These tools empower you to skillfully meet each moment with unshakable peace and wellbeing - no matter how challenging or difficult your situation. They comprise a tool belt of essential practices that can help you experience true health, resiliency, and well-being throughout your life. I call the various practices that make up the iRest program “tools for life”. I’m happy to report, iRest meditation is now taught and practiced world wide. iRest is based on ancient Yoga Nidra teachings, but designed for modern day living. I wanted to make the practice of meditation easier to do and more applicable to our modern, western world so I developed iRest. I later adapted these ancient practices in an effort to make them more accessible - so more people could experience deep healing and well-being. In the following decades, my yearning would lead me to study with some of the most renowned meditation teachers in the world and to become a skilled practitioner - both by continuing my own practice and by sharing this practice with others. This experience left a deep longing in me to understand the practice of Yoga Nidra and to realize this feeling of peace and connectedness. Instead of having my usual feelings of separation and loneliness, I felt connected, both to myself and everything around me. That night, I walked home feeling totally at ease and radiantly joyful within myself. So, during the 12 weeks of my course, I didn’t meet a single person - but I ended up meeting myself - and this became a major turning point in my life.Īt the end of the first class, the instructor taught us a basic Yoga Nidra meditation. When I showed up for my first class, I found out that the instructor had decided to teach the class in total silence. I decided to meet people by taking a 12 week yoga course. I first became involved with Yoga Nidra in 1970, when I moved to San Francisco. Please feel free to check out our Guidestar profile here. By adding information about our goals, strategies, capabilities, achievements, and progress indicators, we are highlighting the difference we help make in the world and our commitment to transparency. IRest Institute has earned Gold Seal of Transparency on GuideStar USA. Our VISION is a peaceful world in which misperceptions that lead to suffering are resolved, and individual and global well-being are valued, nourished, and supported. We do this by offering educational programs, professional meditation teacher training, and opportunities for self-discovery. Our MISSION is to provide people and communities with resources that transform suffering into growth, build deep resilience, and inspire insight and lasting equanimity. Army Surgeon General has listed Yoga Nidra (based on research with iRest) as a Tier 1 approach for addressing Pain Management in Military Care. Based on current studies with iRest in the military, the Defense Centers of Excellence has approved iRest as a Complementary and Alternative Medicine warranting continuing research for its use in the treatment of PTSD. We offer programs in yoga studios, community centers, clinics, schools, hospices, correctional facilities, and U.S. IRest is practiced and taught by thousands of people worldwide in a number of different organizations that support well-being. iRest is designed to bring the healing benefits of yogic and meditative practices to a wide variety of people. IRest Institute is an educational non-profit that provides events, teacher trainings, and educational content based on the ancient teachings of Yoga Nidra but presented in a form made accessible for modern-day living. ![]() ![]() I like that it's a lot of simple metaphors, like this thing about the road. "It's beautiful that the piano's out of tune. "Eighteen minutes in and we discover this about the guy," says Cholodenko. Annette Bening did that a lot on The Kids Are All Right (2010)."īobby then climbs atop a truck bed carting a piano and bangs out a song over the din of honking horns as the truck pulls away. I try to be very clear about what scripts and actors are about, where they're headed, and holding that space, and it's allowed me to let the actor go off book, to add things I might not have thought of. ![]() "You sense this openness between actor and director," says Cholodenko. First he gets out of his car, perturbed, and yells at drivers, a scene that shows Nicholson in full tantrum mode. The next hint that Bobby isn't really a blue-collar guy is during a traffic jam on a highway. Traditional Hollywood is close-ups and medium shots and overs, and this is very anti-Hollywood."Įxposed: Cholodenko admires how the film objectively presents the rather unpleasant world of its anti-hero Bobby Dupea, played by Jack Nicholson (bottom) with his girlfriend Karen Black. (Photo/Screenpulls: (top) Columbia/Photofest (bottom) The Criterion Collection) It's brave to trust your actors like that, to let the performances do their thing. ![]() It's a two-shot that isn't milking the emotion. "There's not a lot of cutting, which gives the comedy a tension," explains Cholodenko, who notices that Rafelson takes the same approach when Bobby goes out to the parking lot to console Rayette, who's moping in the car. Their silly, smiling exchange is mostly played out in one take framing Bobby's head between theirs. Bobby stays behind to flirt with a pair of women one lane over. Later at a bowling alley with an oil rig pal and his wife, Bobby patronizes Rayette, who leaves in a huff. He doesn't respect her.' You started off wondering where you are, but these little things help put it together, but in a fun way." It's a small gesture, but you're like 'OK, I kind of get this guy. Reacting to the music and Rayette says a lot. Plus, obviously, what the song is about: stand by your man." Though no one's said anything yet, a few shots of Bobby hesitating, entering and It was a way to identify with the real world. "At that time, there was a trend away from traditional score, and they used these needle drops. "It's diegetic and non-diegetic sound," says Cholodenko. The Wynette song, we learn, is a source score of sorts, since it's playing on the phonograph of the modest one-bedroom house he shares with his girlfriend, diner waitress/aspiring country singer Rayette (Karen Black). "It introduced a kind of palette with this amber, magic-hour look. "I rememberīeing impressed by these shots," says Cholodenko. As the sun sets, and Bobby drives away, Tammy Wynette's doleful "Stand By Your Man" replaces the sound of machinery. Rafelson's movie, considered an early benchmark of the new golden age of cinema, dips into the peripatetic life of willful outsider Bobby Dupea (Jack Nicholson), whom we meet in the opening montage of still shots as he works on an oil rig against a big sky. It just had this searing impact on me, from script to visuals, all the components. "I was a teaching assistant for Andrew Sarris at Columbia, and he showed this film in his 'Cinema of the '70s' class. ![]() Wise Library at the DGA to watch Bob Rafelson's 1970 masterpiece Five Easy Pieces. I just had a visceral reaction to it," says Lisa Cholodenko as she settles into a chair in the Robert E. ![]() ![]() ![]() Undergoing surgery such as fundoplication, which wraps the upper part of the stomach around the esophagus, which strengthens the valve between the two organs.Using prescription medication, like famotidine and cimetidine, reduces or blocks acid production.Taking over-the-counter antacids, like Tums and Pepto Bismol. ![]() Note: GERD is not life-threatening, but continued esophageal inflammation can lead to more serious problems like esophagitis and could require further treatments and even surgery. If you are also experiencing heartburn, difficulty swallowing, chronic coughing, and disrupted sleep, your nausea may be due to GERD. Clarke, MD, a clinical assistant professor of Gastroenterology Emeritus and assistant director at the Center for Ethics at Oregon Health & Science University. Gastroesophageal reflux disease (GERD), aka acid reflux, occurs when stomach acid flows up into the esophagus, inflaming it, which can trigger nausea, says David D. If you think your nausea is due to an allergy, get tested by an allergist who can help you determine which foods may be to blame. When you eat something you are allergic or have an intolerance to, your body’s immune system responds with chemicals, like immunoglobulin E (IgE) and histamine, that can cause symptoms such as nausea, says Sonpal. Important: Visit a doctor immediately if you experience bloody vomit or bowel movements, extreme pain, blurry vision, or diarrhea for more than three days. If you are also experiencing diarrhea, fever, vomiting, and stomach cramps, your nausea is most likely due to food poisoning. That’s why pre-packaged and raw foods, like salad, fruits, and undercooked meat are common culprits of food poisoning since they’re uncooked, says Sonpal. Usually, bacteria that cause food poisoning die when exposed to temperatures higher than 140 degrees Fahrenheit. These foods are contaminated with either a virus or bacteria which disrupts the GI tract triggering nausea and, oftentimes, vomiting, says Houghton. It’s well known that food poisoning can cause nausea. “The rise of estrogen or the change in the balance of the bacteria in the gut during pregnancy could be another reason nausea after eating increases,” says Niket Sonpal, MD, an internist and gastroenterologist. That’s because pregnant people produce the hormone human chorionic gonadotropin (HCG), which comes with nausea as a side effect. Nausea during pregnancy doesn’t just happen in the morning, it can also occur after lunch, dinner, and snacks. If you do experience nausea after eating, here are seven of the most common causes and how to properly treat it. Houghton, MD, FACG, the senior medical director of Gastroenterology at SOMC Gastroenterology Associates. Most people have felt nauseous at some point in their life - the queasy, upset feeling in your stomach that may make you feel like vomiting.įor some, this uncomfortable sensation occurs after eating, usually 30 to 60 minutes following a meal, and it may last one to three hours, says Jesse P. ![]()
![]() ![]() When using a search engine such as Google, Bing or Yahoo check the safe search settings where you can exclude adult content sites from your search results Īsk your internet service provider if they offer additional filters īe responsible, know what your children are doing online. Use family filters of your operating systems and/or browsers ![]() Other steps you can take to protect your children are: More information about the RTA Label and compatible services can be found here. Parental tools that are compatible with the RTA label will block access to this site. We use the "Restricted To Adults" (RTA) website label to better enable parental filtering. Protect your children from adult content and block access to this site by using parental controls. PARENTS, PLEASE BE ADVISED: If you are a parent, it is your responsibility to keep any age-restricted content from being displayed to your children or wards. Personally dont see Tsurugi so much engaging femdom, but rather being an Assertive Girl who sought to kill two birds with one stone - (1) get over the boys. Furthermore, you represent and warrant that you will not allow any minor access to this site or services. This website should only be accessed if you are at least 18 years old or of legal age to view such material in your local jurisdiction, whichever is greater. You are about to enter a website that contains explicit material (pornography). Monster Girl Island Monthly Patreon choice Hentai game Ep.7 shark mermaid massage on the beach 15 min Cumingaming - 82k Views - 1080p MonsterGirl Island Monthly Hentai game Ep.13 Discovering a shape shifter hot smile girl with growing boobs on the beach 25 min Cumingaming - 44. ![]() ![]() ![]() I think what you are after is ear training more than music theory.Īnyway, do both, learn basic music theory from online resources, but make sure that you train your ear to hear it. But you will not likely use it in your playing. Music theory can be complicated at the advanced level. If after this you want more ear training there won't be better training than learning the chords to songs that you like (and songs you don't like) and analyzing them to see how they fit (or how they diverge from) your current understanding of harmony. These tools are your technique, your ear and your harmonic understanding, but don't waste time overemphasizing the ear training. The objective is to build the tools to free your creative side. Just play around with these ear training apps for something like 10 minutes a day and not too much more, and focus the rest of your efforts on studying the instrument itself. OpenEar - An open source alternative which isn't as flashy but seems to work great.Functional Ear Trainer - Do the Intro Game then go to Basic Training and to the trainings in order.Most apps usually present the intervals isolated from a musical context, which just ain't helpful in the beginning stages, as you have to understand and internalize the sounds of the intervals a context. Instead of getting an ear trainer person I'd get an ear trainer app but one that focuses on the intervals within a musical context. Hey there! Regarding the ear training, I'd like to recommend something that has been helping me improve in strides. You can start noticing how music changes keys and scales it uses and try to understand it and when you notice a thing you don't recognize, do research or ask us. I recommend setting button labels into Movable Do La minor and singing the notes out loud.Īlso /u/DRL47 is entirely right and I want to piggy back on him. This is the sort of 5-10 minutes a day for months kind of project. I found its desktop predecessor very helpful in learning to play melodies by ear, if you're into that, so I've recommended this app to my friends previously. If you don't do ear training, I recommend you to start as well as you probably now gather that most music only uses a a subset of the 12 notes for the most part. Playing scales with both hands at the same time is a more advanced skill and most practical when formal music education or exams require it and if you do decide to master them, you can put your single hand skills in good use later. That way you need to think more and that's a desirable kind of challenge. You can generate a random note/scale with this, which I think is better than just following a pattern such as the circle of fifths. ![]() You can also play scales one hand at a time 4 octaves up and down with a metronome, starting much slower than you think you need. Learning the minor scales would be a good next step. Similarly I learnt key signatures simply by osmosis, flashcards would perhaps have been more efficient. I learnt my scales simply by playing actual music for years and then just got used to actual decent fingerings for each scale. ![]() So what you're going to do next depends wholly on your goals. Functional ear training is the key to understanding what you hear. If you think of function instead, then once you figure out the key of a piece, you can start finding each part separately, so if you make an error (or some parts are hard and you want to skip them), you can just continue from the next phrase and get back on track. Never saw any progress with just drilling intervals despite singing and playing quite a lot.Īnd also it's more useful when playing by ear: Relying on intervals is hard because then you need to get everything correct or your entire piece gets shifted and you won't realize where you made the mistake and why it sounds so wrong. To me it's so much easier that way, and I can actually see progress when training that. ![]() You could start singing your favourite tunes in movable do solfege, or use a training app such as Functional Ear Trainer for Android. Instead of learning to recognize an interval out of context, learn to recognize where individual notes fall relative to the key. ![]() ![]() ![]() Larger companies began to have dedicated IT departments. These managers were responsible for backing up important business data, maintaining desktop hardware, updating and installing new hardware throughout the company, and adding new hardware as it became available. How do you manage the Local Area Network (LAN)? Who manages it? Who grants and restricts privileges to users? Companies began to employ network managers to ensure smooth operation of their Local Area Network. This is an early form of cloud computing. These applications and data were available to employees who connected via the LAN. These in-house systems ran applications on local machines while business data was stored on a central computer. The hub-and spoke model that was used in early SaaS systems is now Local Area Networks (LANs). Companies no longer have time-sharing systems that allow multiple employees to share one computer. This shift was evident in the late 1980s, early 1990s.Ĭomputers are now more affordable than ever in history. Computers in the 1980s & 1990s: The Shrinking Price of Computersĭue to the declining cost of computers, the SaaS market would change. It was rare to need larger files because all data was sent as text. The interfaces were simple and text-based. The system required a dedicated telephone line and modem to send data to clients. SaaS systems were used for key products like CRM, payroll, accounting, and other services. Despite the decreasing cost and size of computers, many businesses still consider SaaS more cost-effective. This type of SaaS was used in the 1970s and 1980s. These organizations couldn’t afford to purchase computer hardware, customer support or training, so they turned to SaaS in order to keep their businesses competitive. This system allows small and medium-sized businesses, educational institutions, government agencies, and other organizations to have access to modern computer systems at a very low cost. It was an early way to connect computers together, which we now call the “internet”. Then, output was sent from the mainframe/mini-computer to the appropriate terminal monitor. To use the system, you must input data via the terminal keyboard. All data and applications were kept on the mainframe. They were connected to a mainframe/mini-computer using a hub-and spoke system. This system used multiple “dumb terminals”, which were keyboards or monitors without CPUs. The 1960s model that we now call “cloud computing” or “SaaS” was originally known as a “time sharing” system. Software was created as a service industry. Computers were prohibitively expensive and unaffordable for small and medium-sized companies. SaaS has been a well-established business model since the 1960sĬomputers were large and expensive in the 1960s. Now that we have defined SaaS, we can talk about where SaaS actually started. The provider will then send all app-related information to your computer via the internet. Your data is sent directly to the provider. The application is hosted elsewhere and is not stored on your computer. What is the difference between SaaS and traditional software? As a SaaS customer, your data is transferred to the SaaS provider over a network (like the internet). Other popular SaaS platforms are office and messaging, payroll processing and accounting software. These terms are part the general nomenclature of cloud computing.Ĭustomer relationship management software (CRM), is the most popular SaaS type today. It can be used interchangeably to refer to infrastructure, platform, and desktop services (IaaS), mobile backend, and managed software-as-services (MSaaS). SaaS can be synonymous with cloud computing. SaaS can be described as a broad term that can mean many things. What is Software as a Service?īefore we get into the history and evolution SaaS, let us first define what SaaS is. What is the history behind Software as a service? Learn more about SaaS today. SaaS is more popular than ever because of the internet and global communication technologies. SaaS was introduced to the world with the 1960s computers. SaaS is often used interchangeably with “cloud computing” today. SaaS refers to a business model where customers pay for software hosted on remote computers. We’ll also speculate about the future direction of SaaS. We’ll also examine some of the factors behind SaaS’s adoption. This article will explore software as a service history - its origins and its growth over time. Software as a Service has come a long way since its inception in the 1960s. ![]() ![]() HID® OMNIKEY® 5025 CL Prox Reader $154. Hid Omnikey, For Higher Education Market Only, 5427 Cntls Smart Card Reader With Usb 2.0, Bluetooth, Dual Freq 13.56mhz/125khz, Native Ccid Keyboard. HID ® OMNIKEY ® 5027 is a high-frequency contactless USB reader with a keyboard wedge interface designed for customers seeking easy integrations with higher security and access management, including healthcare, financial services, enterprise, government, pharmaceuticals and other agencies.HID® OMNIKEY® 5427ck Gen2 Dual-Frequency Reader – BLE Mobile Access $352.00 Add to cart.HID® OMNIKEY® 3121 USB Smart Card Reader $71.50 Add to cart.HID® OMNIKEY® 5427ck Gen2 Dual-Frequency Reader – NO BLE Mobile Access Model $330.00 Add to cart.Click here to access the reader data sheet. ![]() I specially like the plastic injected molding in the Model M so the keys dont wear out, I dont think the Omnikeys ever had that feature. Ease of configuration – with the Workbench Tool, configuration file or cards I personally owned the original IBM XT keyboard as well an Omnikey (not-ultra) plus the myriads of knock-off cheapies, BTC, and Logitech keyboards but no Model M. ![]() Preconfigured – by default, for an easy output of most common credentials HID Global’s OMNIKEY 5027 is an easy to use, keyboard wedge interface card reader.High-frequency credentials supported – including iCLASS Seos®, iCLASS SE®, MIFARE Classic® and MIFARE® DESFire® EV1/EV2 as well as NFC Buy Hid Omnikey, 5427 Contactless Smart Card Reader Gen 2, USB 2.0, Removable Card Retainer, Dual Freq Read, Native Ccid Keyboard Emulation Dtk Avail.Easy to integrate – straightforward utilization of existing access control credentials based on keyboard wedge.Typical environments for the reader include healthcare, financial services, enterprise and government. HID OMNIKEY 5127CK Mini CCID & Keyboard Wedge Reader HID OMNIKEY 5127CK Reader Board HID OMNIKEY 5127CK Reader Core HID OMNIKEY 5422 HID OMNIKEY 5427 CK HID OMNIKEY 6121 Mobile USB OS Windows 10 32-Bit Windows 10 64-Bit Windows 10 圆4 Windows 10 x86 Windows 8.1 x32 Windows 8. ![]() Easy configuration is available for different operating systems and card populations, as well as integration for various existing environments (ideal for SSO). For common cards and use cases, the reader comes preconfigured and ready to use out of the box. HID® OMNIKEY® 5027 high-frequency contactless reader with keyboard wedge interface is designed for customers seeking easy integrations with higher security and access management who want to utilize their existing access control badges for authentication to computers, networks or cloud applications beyond physical access control. ![]() ![]() However, these findings are based on binary comparisons based on sex, and it is important to broaden the current understanding of immunity to include transgender individuals. Additionally, sexual dimorphism exists within several immunological diseases, such as the heightened prevalence of some autoimmune and inflammatory diseases among adult individuals presumed female at birth compared to adult individuals presumed male at birth. In those seeking feminization, GAHT includes oestrogen (in the presence of absence of progesterone) in combination with anti-androgens, while testosterone therapy is used for those seeking masculinization.Ī wealth of research exists on ‘sex-specific’ immunity, including evidence of sex-specific vaccine and infection responses (reviewed in ). In those where these are markedly and consistently incongruent, as in the case of transgender individuals, feminization or masculinization may be sought through gender-affirming hormone therapy (GAHT). Gender dysphoria occurs when an individual’s gender identity and sex assigned at birth do not align. ‘Gender identity’ refers to one’s self-perception of gender, while ‘sex’ refers to the underpinning biological features, which is assigned at birth and defined by reproductive anatomy or sex chromosomes. Although often used interchangeably, gender and sex are separate constructs. In the era of personalized medicine, inclusivity of all genders and sexes in research is vital for providing equitable and inclusive health care. We highlight the need to broaden the field of ‘sex-specific’ immunity beyond cisgender males and cisgender females, as transgender people on GAHT exhibit a unique molecular profile. This study advances our understanding of the complex interplay between sex hormones, sex chromosomes, and DNA methylation in the context of immunity. We provide evidence for GAHT inducing a unique blood methylation signature in transgender people. The GAHT-induced changes at these sex-associated probes consistently demonstrated a shift towards the methylation signature of the GAHT-naïve opposite sex, and we observed enrichment of previously reported adolescence-associated methylation changes. The small number of sex-specific DMPs that were affected by GAHT were those that become sex-specific during the lifetime, known as sex-and-age DMPs, including DMRs in PRR4 and VMP1 genes. ![]() X chromosome and sex-specific autosomal DNA methylation patterns established in early development are largely refractory to change in association with GAHT, with only 3% affected (Δ β ≥ 0.02, unadjusted p value < 0.05). We identified several thousand differentially methylated CpG sites (DMPs) (Δ β ≥ 0.02, unadjusted p value < 0.05) and several differentially methylated regions (DMRs) in both people undergoing feminizing and masculinizing GAHT, the vast majority of which were progressive changes over time. We profiled genome-wide DNA methylation in blood of transgender women ( n = 13) and transgender men ( n = 13) before and during GAHT (6 months and 12 months into feminizing or masculinizing hormone therapy). GAHT is a cornerstone of transgender care, yet no studies to date have investigated its effect on genome-wide methylation. In individuals where gender identity and sex assigned at birth are markedly incongruent, as in the case of transgender people, feminization or masculinization may be sought through gender-affirming hormone therapy (GAHT). In addition to X-linked DNA methylation, sex-specific methylation patterns are widespread across autosomal chromosomes and can be present from birth or arise over time. ![]() DNA methylation is an epigenetic mark that is influenced by underlying genetic profile, environment, and ageing. ![]() |